Inclusion Complex of β - Cyclodextrin and Quercetin . Thermodynamic Approach
نویسنده
چکیده
CSABA PAL RACZ1, ROXANA-DIANA PASCA1, SANTA SZABOLCS1, IRINA KACSO2, GHEORGHE TOMOAIA3, AURORA MOCANU1, OSSI HOROVITZ1, MARIA TOMOAIA-COTISEL1* 1Babes-Bolyai University of Cluj-Napoca, Faculty of Chemistry and Chemical Engineering, Department of Physical Chemistry, 11 Arany J. Str., 400028 Cluj-Napoca, Romania 2National Institute of Research and Development for Molecular and Isotopic Technologies of Cluj-Napoca, 65-103 Donath Str., 400293 Cluj-Napoca, Romania 3Iuliu Hatieganu University of Medicine and Pharmacy, 13 E. Isac Str., 400023 Cluj-Napoca, Romania
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Thermodynamic, spectral and antimicrobial activity of inclusion complexes of acridone and its oxime with β-cyclodextrin
One of the methods to enhance bio-accessibility of drugs like Acridone and its oxime is toform inclusion complexes with β-cyclodextrin. The formation of such complexes has beenconfirmed by changes in spectral characteristics and melting point data. The aqueous phasesolubility studies reveal 1:1 stoichiometry between the compound and, β-cyclodextrin. The studyof thermodynamic parameters like ΔG,...
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